Researchers conducted a study to determine how brain volume changes individuals subjected to mild traumatic brain injury (mTBI) and how that change affects cognitive abilities in those individuals after one year.
The study observed two groups of patients: subjects suffering posttraumatic symptoms following mTBI and a control group who had not suffered traumatic brain injury. At the start of the study and in the follow-up one year later, researchers used an MRI to determine the volumes of gray and white brain matter in each patient; determined neurocognitive scores, and recorded clinical metrics.
The follow-up revealed more global brain atrophy in the mTBI subjects than in the control subjects; and atrophy in the mTBI subjects that correlated to anxiety, post-concussive symptoms, and altered memory and attention.
Zhou Y, Kierans A, et al. Mild Traumatic Brain Injury: Longitudinal Regional Brain Volume Changes. Radiology. (June 2013).