Changes in Mouse Cognition and Hippocampal Gene Expression Observed in a Mild Physical-and Blast-Traumatic Brain Injury

Doctors Reviewing Brain Imaging on Computer Monitor

In a recent study, researchers compared the effects of traumatic brain injury caused by physical impact and high-velocity blast shockwaves.

The researchers subjected mice to mild types of physical or blast-induced TBI and then evaluated the mice using a number of metrics, including cognitive and emotional behavior, recognition and spatial memory, and anxiety.

The study concluded that molecular pathways of both forms of TBI can lead to Alzheimer's disease, but are distinct in terms of gene expression regulation; and suggests that while victims of each form of TBI display similar behavioral and emotional changes, researchers may need to develop different therapeutic approaches to treat these injuries.

Tweedie D, Rachmany L, et al. Changes in Mouse Cognition and Hippocampal Gene Expression Observed in a Mild Physical-and Blast-Traumatic Brain Injury. Neurobiology of Disease. (June 2013).