Role of Anticonvulsants in the Management of Posttraumatic Epilepsy

Posttraumatic seizures (PTS) are a common and major problem associated with traumatic brain injury (TBI) because of the secondary damages they can produce in the brain. Anticonvulsant medications, which can reduce brain damage by preventing early seizures, are a typical treatment for seizures in general, but their role in treating posttraumatic epilepsy (PTE) is unclear.

A recent literature review investigated how anticonvulsants work during treatment for PTS. Past research on the relationship between anticonvulsants and PTE has shown that these medications are beneficial for preventing seizures that occur in the first seven days after the injury, but that they have no significant preventative effect for “late” PTS—seizures occurring after seven days after the injury.

Despite modern advancements in medication, adequate treatment of PTE remains a challenge. Due to the limited long-term preventative effects of anticonvulsant medication, alternative treatments may be necessary to minimize the neurological consequences of TBI-related seizures.

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