Posttraumatic seizures (PTS) are a common and major problem associated with
traumatic brain injury (TBI) because of the secondary damages they can produce in the brain.
Anticonvulsant medications, which can reduce brain damage by preventing
early seizures, are a typical treatment for seizures in general, but their
role in treating posttraumatic epilepsy (PTE) is unclear.
A recent literature review investigated how anticonvulsants work during
treatment for PTS. Past research on the relationship between anticonvulsants
and PTE has shown that these medications are beneficial for preventing
seizures that occur in the first seven days after the injury, but that
they have no significant preventative effect for “late” PTS—seizures
occurring after seven days after the injury.
Despite modern advancements in medication, adequate treatment of PTE remains
a challenge. Due to the limited long-term preventative effects of anticonvulsant
medication, alternative treatments may be necessary to minimize the neurological
consequences of TBI-related seizures.